376 research outputs found
Sound Theology: The Risk of Audition
(Excerpt)
It was after I had settled on a tide for this presentation that the irony of it all hit me. Thinking about being on this campus and holding forth on the topic on sound theology and the risk of audition, I was suddenly reminded of an autumn day In 1968, when I first came to this University, played an organ audition with then reigning chapel organist, Dr. Philip Gehring. As I reflect back, however, I am not sure whether that experience should be appropriately categorized as a risk or musicological embarrassmen
The Lantern Vol. 46, No. 1, December 1979
• Visions in Chains • The Bean • Who Can We Watch Tonite? • Night Glider • The Hurricane • Crisp New Paper • Compassion • Loneliness • 301 • Ode to Man • Unsteady Hands • The Beachcomber • The Pounce • Graveyard Shift • Houston Refineries • Haiku • The End of the Game • A Rose • Ode to a Ziffle • To Carson McCullers • In the May Month • Ghostly Chanting • Travel Excerpts • Face in the Crowd • Waiting in an Airport • A Taste of Winter\u27s Embracehttps://digitalcommons.ursinus.edu/lantern/1115/thumbnail.jp
Using airborne LiDAR Survey to explore historic-era archaeological landscapes of Montserrat in the eastern Caribbean
This article describes what appears to be the first archaeological application of airborne LiDAR survey to historic-era landscapes in the Caribbean archipelago, on the island of Montserrat. LiDAR is proving invaluable in extending the reach of traditional pedestrian survey into less favorable areas, such as those covered by dense neotropical forest and by ashfall from the past two decades of active eruptions by the Soufrière Hills volcano, and to sites in localities that are inaccessible on account of volcanic dangers. Emphasis is placed on two aspects of the research: first, the importance of ongoing, real-time interaction between the LiDAR analyst and the archaeological team in the field; and second, the advantages of exploiting the full potential of the three-dimensional LiDAR point cloud data for purposes of the visualization of archaeological sites and features
First-year Sloan Digital Sky Survey-II (SDSS-II) Supernova Results: Hubble Diagram and Cosmological Parameters
We present measurements of the Hubble diagram for 103 Type Ia supernovae
(SNe) with redshifts 0.04 < z < 0.42, discovered during the first season (Fall
2005) of the Sloan Digital Sky Survey-II (SDSS-II) Supernova Survey. These data
fill in the redshift "desert" between low- and high-redshift SN Ia surveys. We
combine the SDSS-II measurements with new distance estimates for published SN
data from the ESSENCE survey, the Supernova Legacy Survey, the Hubble Space
Telescope, and a compilation of nearby SN Ia measurements. Combining the SN
Hubble diagram with measurements of Baryon Acoustic Oscillations from the SDSS
Luminous Red Galaxy sample and with CMB temperature anisotropy measurements
from WMAP, we estimate the cosmological parameters w and Omega_M, assuming a
spatially flat cosmological model (FwCDM) with constant dark energy equation of
state parameter, w. For the FwCDM model and the combined sample of 288 SNe Ia,
we find w = -0.76 +- 0.07(stat) +- 0.11(syst), Omega_M = 0.306 +- 0.019(stat)
+- 0.023(syst) using MLCS2k2 and w = -0.96 +- 0.06(stat) +- 0.12(syst), Omega_M
= 0.265 +- 0.016(stat) +- 0.025(syst) using the SALT-II fitter. We trace the
discrepancy between these results to a difference in the rest-frame UV model
combined with a different luminosity correction from color variations; these
differences mostly affect the distance estimates for the SNLS and HST
supernovae. We present detailed discussions of systematic errors for both
light-curve methods and find that they both show data-model discrepancies in
rest-frame -band. For the SALT-II approach, we also see strong evidence for
redshift-dependence of the color-luminosity parameter (beta). Restricting the
analysis to the 136 SNe Ia in the Nearby+SDSS-II samples, we find much better
agreement between the two analysis methods but with larger uncertainties.Comment: Accepted for publication by ApJ
Adipocyte-specific protein tyrosine phosphatase 1B deletion increases lipogenesis, adipocyte cell size and is a minor regulator of glucose homeostasis
Peer reviewedPublisher PD
First-Year Spectroscopy for the SDSS-II Supernova Survey
This paper presents spectroscopy of supernovae discovered in the first season
of the Sloan Digital Sky Survey-II Supernova Survey. This program searches for
and measures multi-band light curves of supernovae in the redshift range z =
0.05 - 0.4, complementing existing surveys at lower and higher redshifts. Our
goal is to better characterize the supernova population, with a particular
focus on SNe Ia, improving their utility as cosmological distance indicators
and as probes of dark energy. Our supernova spectroscopy program features
rapid-response observations using telescopes of a range of apertures, and
provides confirmation of the supernova and host-galaxy types as well as precise
redshifts. We describe here the target identification and prioritization, data
reduction, redshift measurement, and classification of 129 SNe Ia, 16
spectroscopically probable SNe Ia, 7 SNe Ib/c, and 11 SNe II from the first
season. We also describe our efforts to measure and remove the substantial host
galaxy contamination existing in the majority of our SN spectra.Comment: Accepted for publication in The Astronomical Journal(47pages, 9
figures
The Redshift Completeness of Local Galaxy Catalogs
There is considerable interest in understanding the demographics of galaxies within the local universe (defined, for our purposes, as the volume within a radius of 200 Mpc or z ≤ 0.05). In this pilot paper, using supernovae (SNe) as signposts to galaxies, we investigate the redshift completeness of catalogs of nearby galaxies. In particular, type Ia SNe are bright and are good tracers of the bulk of the galaxy population, as they arise in both old and young stellar populations. Our input sample consists of SNe with redshift ≤0.05, discovered by the flux-limited ASAS-SN survey. We define the redshift completeness fraction (RCF) as the number of SN host galaxies with known redshift prior to SN discovery, determined, in this case, via the NASA Extragalactic Database, divided by the total number of newly discovered SNe. Using SNe Ia, we find % (90% confidence interval) for z < 0.03. We examine the distribution of host galaxies with and without cataloged redshifts as a function of absolute magnitude and redshift, and, unsurprisingly, find that higher-z and fainter hosts are less likely to have a known redshift prior to the detection of the SN. However, surprisingly, some galaxies are also missing. We conclude with thoughts on the future improvement of RCF measurements that will be made possible from large SN samples resulting from ongoing and especially upcoming time-domain surveys
Constant light enhances synchrony among circadian clock cells and promotes behavioral rhythms in VPAC(2)-signaling deficient mice
Individual neurons in the suprachiasmatic nuclei (SCN) contain an intracellular molecular clock and use intercellular signaling to synchronize their timekeeping activities so that the SCN can coordinate brain physiology and behavior. The neuropeptide vasoactive intestinal polypeptide (VIP) and its VPAC2 receptor form a key component of intercellular signaling systems in the SCN and critically control cellular coupling. Targeted mutations in either the intracellular clock or intercellular neuropeptide signaling mechanisms, such as VIP-VPAC2 signaling, can lead to desynchronization of SCN neuronal clocks and loss of behavioral rhythms. An important goal in chronobiology is to develop interventions to correct deficiencies in circadian timekeeping. Here we show that extended exposure to constant light promotes synchrony among SCN clock cells and the expression of ~24 h rhythms in behavior in mice in which intercellular signaling is disrupted through loss of VIP-VPAC2 signaling. This study highlights the importance of SCN synchrony for the expression of rhythms in behavior and reveals how non-invasive manipulations in the external environment can be used to overcome neurochemical communication deficits in this important brain system
Pathway-based expression profiling of benign prostatic hyperplasia and prostate cancer delineates an immunophilin molecule associated with cancer progression
Aberrant restoration of AR activity is linked with prostate tumor growth, therapeutic failures and development of castrate-resistant prostate cancer. Understanding the processes leading to ARreactivation should provide the foundation for novel avenues of drug discovery. A differential gene expression study was conducted using biopsies from CaP and BPH patients to identify the components putatively responsible for reinstating AR activity in CaP. From the set of genes upregulated in CaP,
FKBP52, an AR co-chaperone, was selected for further analysis. Expression of FKBP52 was positively correlated with that of c-Myc. The functional cross-talk between c-Myc and FKBP52 was established using c-Myc specific-siRNA to LNCaP cells that resulted in reduction of FKBP52. A non-canonical E-box sequence housing a putative c-Myc binding site was detected on the FKBP4 promoter using in silico
search. LNCaP cells transfected with the FKBP52 promoter cloned in pGL3 basic showed increased luciferase activity which declined considerably when the promoter-construct was co-transfected with c-Myc specific-siRNA. ChIP-PCR confirmed the binding of c-Myc with the conserved E-box located in the
FKBP52 promoter. c-Myc downregulation concomitantly affected expression of FGF8. Since expression of FGF8 is controlled by AR, our study unveiled a novel functional axis between c-Myc, AR and FGF8 operating through FKBP52
- …